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Current status of pathogenetic mechanisms in staphylococcal arthritis.

Review article
Authors Andrej Tarkowski
Maria Bokarewa
Vincent Collins
Inger Gjertsson
Olof H. Hultgren
Tao Jin
Ing-Marie Jonsson
Elisabet Josefsson
Egidija Sakiniene
Margareta Verdrengh
Published in FEMS microbiology letters
Volume 217
Issue 2
Pages 125-32
ISSN 0378-1097
Publication year 2002
Published at Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
Pages 125-32
Language en
Keywords Animals, Arthritis, Infectious, immunology, microbiology, therapy, Chemokines, metabolism, Cytokines, metabolism, Immunity, Active, Joints, microbiology, Mice, Staphylococcal Infections, immunology, microbiology, therapy, Staphylococcus, classification, metabolism, pathogenicity, Treatment Outcome, Virulence Factors, metabolism
Subject categories Infectious Medicine


Interactions between staphylococci and the joint tissues of the host lead typically to rapidly progressing and highly destructive processes. Staphylococci possess a vast arsenal of components and products that contribute to the pathogenesis of joint infection. Occasionally these compounds have overlapping activities and act either in concert or alone. Host responsiveness to staphylococcal infection displays an even more complex pattern. Most of the cells and molecules that participate in the innate immune system protect the host against bacteria. However, the staphylococci have developed systems that counteract endogenous protective mechanisms. Interestingly, certain cells and molecules of the acquired immune system potentiate the severity of infection by triggering exaggerated responses to the staphylococcal danger signals. This review deals with the intricate host-bacterium interactions that occur during experimental septic arthritis, and outlines potential preventive and treatment modalities.

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