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The haptoglobin 2-2 genotype is associated with carotid atherosclerosis in 64-year old women with established diabetes.

Journal article
Authors Mikael Ryndel
Carl Johan Behre
Gerhard Brohall
Ulrica Prahl
Caroline Schmidt
Göran Bergström
Björn Fagerberg
Fredrik J. Olson
Published in Clinica chimica acta; international journal of clinical chemistry
ISSN 1873-3492
Publication year 2010
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Language en
Keywords Arteriosclerosis, Cardiovascular risk factors, Carotid intima-media thickness, Diabetes mellitus, Haptoglobin, Polymorphism
Subject categories Medical and Health Sciences, Clinical physiology, Cardiovascular medicine, Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)


BACKGROUND: Haptoglobin polymorphism generates three common human genotypes: Hp1-1, Hp2-1 and Hp2-2. Among subjects with diabetes, Hp2-2 is associated with an elevated risk to develop cardiovascular disease. The impact of haptoglobin genotype on subclinical carotid atherosclerosis is not known. We hypothesised that Hp2-2 was associated with increased occurrence of carotid atherosclerosis in subjects with diabetes. METHODS: We studied a population-based sample of 64-year old women with diabetes (n=226), either established diabetes known before study entry (n=116) or new diabetes detected at study screening. Haptoglobin genotype was determined by PCR. Carotid atherosclerosis was assessed by ultrasound imaging. RESULTS: In the entire diabetes cohort, no differences were observed in carotid intima-media thickness (IMT) or plaque prevalence between the genotype groups. However, among those with established diabetes, Hp2-2 was associated with higher plaque prevalence and larger carotid IMT compared with the Hp2-1 and Hp1-1 genotypes. Common cardiovascular risk factors did not differ between the genotype groups. CONCLUSIONS: The Hp2-2 genotype was associated with increased occurrence of subclinical carotid atherosclerosis in 64-year old women with established diabetes. This association was not explained by traditional risk factors for cardiovascular disease. These results extend previous observations that Hp2-2 is associated with clinical cardiovascular disease in diabetes.

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