To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Elevated cerebrospinal fl… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Elevated cerebrospinal fluid levels of prostaglandin E2 and 15-(S)-hydroxyeicosatetraenoic acid in multiple sclerosis.

Journal article
Authors Niklas Mattsson
M Yaong
Lars Rosengren
Kaj Blennow
Jan-Eric Månsson
Oluf Andersen
Henrik Zetterberg
Sara Haghighi
I Zho
D. Pratico
Published in Journal of internal medicine
Volume 265
Issue 4
Pages 459-64
ISSN 1365-2796
Publication year 2009
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 459-64
Language en
Links dx.doi.org/10.1111/j.1365-2796.2008...
Keywords Adolescent, Adult, Aged, Dinoprostone, cerebrospinal fluid, Female, Gas Chromatography-Mass Spectrometry, Humans, Hydroxyeicosatetraenoic Acids, cerebrospinal fluid, Male, Middle Aged, Multiple Sclerosis, cerebrospinal fluid, Severity of Illness Index, Young Adult, 15-(S)-Hydroxyeicosatetraenoic acid, arachidonic acid, biomarker, inflammation, prostaglandin E2
Subject categories Neurochemistry, Psychiatry

Abstract

OBJECTIVE: To test the hypothesis that the arachodinic acid metabolites prostaglandin E2 (PGE2) and 15-(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) in cerebrospinal fluid (CSF) are elevated and reflect neuroinflammation and degenerative changes in multiple sclerosis (MS). PATIENTS AND METHODS: We measured PGE2 and 15(S)-HETE concentrations, as well as markers of axonal and astroglial injury in CSF from 46 MS patients, 46 healthy siblings and 50 controls. RESULTS: We found elevated levels of both PGE2 and 15(S)-HETE in MS compared with the control and sibling groups. Siblings had lower PGE2 levels and higher 15(S)-HETE levels than controls. There were no correlations between either PGE2 or 15(S)-HETE and clinical scores of MS severity or biochemical markers of axonal or astroglial injury. CONCLUSION: These data suggest no direct involvement of PGE2 and 15(S)-HETE in the MS disease process. Rather, the elevated levels reflect a general up-regulation of arachidonic acid metabolism and neuroinflammation.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?

Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=98747
Utskriftsdatum: 2020-01-20