To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Cerebrospinal fluid viral… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: a longitudinal study

Journal article
Authors Magnus Gisslén
Lars Hagberg
Dietmar Fuchs
Gunnar Norkrans
Bo Svennerholm
Published in J Acquir Immune Defic Syndr Hum Retrovirol
Volume 17
Issue 4
Pages 291-5
Publication year 1998
Published at Institute of Internal Medicine, Dept of Infectious Diseases
Institute of Laboratory Medicine, Dept of Clinical Virology
Pages 291-5
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Adult, CD4 Lymphocyte Count, Cerebrospinal Fluid/*virology, Cohort Studies, Female, Follow-Up Studies, HIV Infections/cerebrospinal fluid/immunology/*virology, HIV-1/genetics/immunology/*physiology, Humans, Longitudinal Studies, Male, Middle Aged, Neopterin/blood/cerebrospinal fluid, Polymerase Chain Reaction, RNA, Viral/blood/*cerebrospinal fluid, *Viral Load
Subject categories Microbiology in the medical area

Abstract

HIV-1 RNA and neopterin levels were observed longitudinally for 20 to 68 months (mean, 37.5 months) in cerebrospinal fluid (CSF) and serum in 15 HIV-1-infected patients not receiving antiretroviral treatment. During the course of infection the HIV-1 RNA levels increased significantly in CSF, from a mean of 3.08 to 3.51 log10 copies RNA/ml (p < .01). A significant positive correlation was found between the CSF levels of HIV-I RNA and neopterin (rs = 0.54; p < .001), which increased from 13.6 to 19.6 nmol/L (p < .01). No significant changes in HIV-1 RNA or neopterin levels were found in serum. We suggest that the increase of CSF viral load with time in HIV-1 infection triggers an intrathecal immune activation reflected by increased CSF levels of neopterin. These results are in accordance with the theory that a chronic immune stimulation within the central nervous system (CNS) is involved in the pathogenesis of neurologic HIV-1 disease.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?

Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=83703
Utskriftsdatum: 2020-05-28