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Reduced immunogenicity of diphtheria and tetanus toxoids when combined with pertussis toxoid.

Journal article
Authors Birger Trollfors
John Taranger
Teresa Lagergård
Valter Sundh
Published in The Pediatric infectious disease journal
Volume 24
Issue 1
Pages 85-6
ISSN 0891-3668
Publication year 2005
Published at Institute of Medical Microbiology/Immunology
Institute of Community Medicine
Institute for the Health of Women and Children, Dept of Paediatrics
Pages 85-6
Language en
Keywords Animals, Antibodies, Bacterial, blood, Cercopithecus aethiops, Child, Preschool, Diphtheria, prevention & control, Diphtheria Toxoid, administration & dosage, immunology, Diphtheria-Tetanus Vaccine, administration & dosage, immunology, Double-Blind Method, Drug Interactions, Humans, Immunoglobulin G, blood, Infant, Tetanus, prevention & control, Tetanus Toxoid, administration & dosage, immunology, Toxoids, administration & dosage, immunology, Vaccines, Acellular, administration & dosage, immunology, Vaccines, Combined, administration & dosage, immunology, Vero Cells, Whooping Cough, prevention & control
Subject categories Medical and Health Sciences


The effect of pertussis toxoid on the immunogenicity of diphtheria and tetanus toxoids (DT) was studied during a double blind efficacy trial of an acellular pertussis vaccine. Infants received DT with or without pertussis toxoid at 3, 5 and 12 months of age. Geometric mean concentrations were higher in the DT than in the DT-pertussis toxoid group 1 month (diphtheria toxoid 4.76 versus 3.58 IU/mL, P = 0.009; tetanus toxoid 4.42 versus 2.66 IU/mL, P < 0.0001) and 2 years after the third injection (diphtheria toxoid 0.15 versus 0.10 IU/mL, P < 0.0001; tetanus toxoid 0.38 versus 0.18 IU/mL, P < 0.0001). Pertussis toxoid causes a small but significant reduction of the immunogenicity of diphtheria toxoid and tetanus toxoid.

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Utskriftsdatum: 2020-07-09