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Ataluren use in patients with nonsense mutation Duchenne muscular dystrophy: patient demographics and characteristics from the STRIDE Registry

Journal article
Authors F. Muntoni
I. Desguerre
M. Guglieri
A. N. Osorio
J. Kirschner
Mar Tulinius
F. Buccella
G. Elfring
C. Werner
T. Schilling
P. Trifillis
O. Zhang
A. Delage
C. L. Santos
E. Mercuri
Published in Journal of Comparative Effectiveness Research
Volume 8
Issue 14
Pages 1187-1200
ISSN 2042-6305
Publication year 2019
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages 1187-1200
Language en
Subject categories Clinical Medicine


Aim: Strategic Targeting of Registries and International Database of Excellence (STRIDE) is an ongoing, multicenter registry providing real-world evidence regarding ataluren use in patients with nonsense mutation Duchenne muscular dystrophy (DMD) in clinical practice (NCT02369731). Here, we describe the initial demographic characteristics of the registry population. Patients & methods: Patients will be followed up from enrollment for >= 5 years or until study withdrawal. Results & conclusion: As of 9 July 2018, 213 DMD boys were enrolled from 11 countries. Mean (standard deviation) ages at first symptoms and at study treatment start were 2.7 (1.7) years and 9.8 (3.7) years, respectively. Corticosteroids were used by 190 patients (89.2%) before data cut-off. Mean (standard deviation) ataluren exposure was 639.0 (362.9) days. Six patients withdrew. STRIDE is the first drug registry for patients with DMD and represents the largest real-world registry of patients with nmDMD to date.

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Utskriftsdatum: 2020-08-10