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Homeostatic Chemokines and Prognosis in Patients With Acute Coronary Syndromes.

Journal article
Authors Kenneth Caidahl
Marianne Hartford
Annica Ravn-Fischer
Erik Lorentzen
Arne Yndestad
Karlsson Thomas
Pål Aukrust
Thor Ueland
Published in Journal of the American College of Cardiology
Volume 74
Issue 6
Pages 774-782
ISSN 1558-3597
Publication year 2019
Published at Core Facilities, Bioinformatics
Institute of Medicine, Department of Molecular and Clinical Medicine
Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
Pages 774-782
Language en
Links dx.doi.org/10.1016/j.jacc.2019.06.0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Cardiovascular medicine

Abstract

The chemokines CCL19 and CCL21 are up-regulated in atherosclerotic disease and heart failure, and increased circulating levels are found in unstable versus stable coronary artery disease.The purpose of this study was to evaluate the prognostic value of CCL19 and CCL21 in acute coronary syndrome (ACS).CCL19 and CCL21 levels were analyzed in serum obtained from ACS patients (n = 1,146) on the first morning after hospital admission. Adjustments were made for GRACE (Global Registry of Acute Coronary Events) score, left ventricular ejection fraction, pro-B-type natriuretic peptide, troponin I, and C-reactive protein levels.The major findings were: 1) those having fourth quartile levels of CCL21 on admission of ACS had a significantly higher long-term (median 98 months) risk of major adverse cardiovascular events (MACE) and myocardial infarction in fully adjusted multivariable models; 2) high CCL21 levels at admission were also independently associated with MACE and cardiovascular mortality during short-time (3 months) follow-up; and 3) high CCL19 levels at admission were associated with the development of heart failure.CCL21 levels are independently associated with outcome after ACS and should be further investigated as a promising biomarker in these patients.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=282833
Utskriftsdatum: 2019-10-15