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Clonal relatedness in tumour pairs of breast cancer patients.

Journal article
Authors Jana Biermann
Toshima Z Parris
Szilard Nemes
Anna Danielsson
Hanna Engqvist
Elisabeth Werner Rönnerman
Eva Forssell-Aronsson
Anikó Kovács
Per Karlsson
Khalil Helou
Published in Breast cancer research : BCR
Volume 20
Issue 1
ISSN 1465-542X
Publication year 2018
Published at Institute of Clinical Sciences, Department of Radiation Physics
Institute of Clinical Sciences, Department of Oncology
Sahlgrenska Cancer Center
Language en
Links dx.doi.org/10.1186/s13058-018-1022-...
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Bilateral breast cancer; Intertumour heterogeneity; Ipsilateral breast cancer; Multiple breast cancer; Similarity index; Tumour clonality
Subject categories Clinical Medicine, Biological Sciences, Health Sciences

Abstract

Molecular classification of tumour clonality is currently not evaluated in multiple invasive breast carcinomas, despite evidence suggesting common clonal origins. There is no consensus about which type of data (e.g. copy number, mutation, histology) and especially which statistical method is most suitable to distinguish clonal recurrences from independent primary tumours.Thirty-seven invasive breast tumour pairs were stratified according to laterality and time interval between the diagnoses of the two tumours. In a multi-omics approach, tumour clonality was analysed by integrating clinical characteristics (n = 37), DNA copy number (n = 37), DNA methylation (n = 8), gene expression microarray (n = 7), RNA sequencing (n = 3), and SNP genotyping data (n = 3). Different statistical methods, e.g. the diagnostic similarity index (SI), were used to classify the tumours as clonally related recurrences or independent primary tumours.The SI and hierarchical clustering showed similar tendencies and the highest concordance with the other methods. Concordant evidence for tumour clonality was found in 46% (17/37) of patients. Notably, no association was found between the current clinical guidelines and molecular tumour features.A more accurate classification of clonal relatedness between multiple breast tumours may help to mitigate treatment failure and relapse by integrating tumour-associated molecular features, clinical parameters, and statistical methods. Guidelines need to be defined with exact thresholds to standardise clonality testing in a routine diagnostic setting.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=269410
Utskriftsdatum: 2019-11-20