To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Impact of psychological h… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Impact of psychological health on peripheral endothelial function and the HPA-axis activity in healthy adolescents

Journal article
Authors Yun Chen
W. Osika
Frida Dangardt
Peter Friberg
Published in Atherosclerosis
Volume 261
Pages 131-137
ISSN 0021-9150
Publication year 2017
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 131-137
Language en
Links doi.org/10.1016/j.atherosclerosis.2...
Keywords Adolescence, Negative emotional status, Self-concept, Peripheral endothelial function, Cortisol awakening response, coronary-heart-disease, cardiovascular-disease, salivary cortisol, physical-activity, children, childhood, stress, associations, dysfunction, depression, Cardiovascular System & Cardiology
Subject categories Clinical Medicine

Abstract

Background and aims: The development of adolescence psychological health over a 3-year period and its relationship to peripheral endothelial function and the hypothalamic-pituitary-adrenal (HPA)-axis activity were examined in a cohort of healthy adolescents in a longitudinal study. Methods: A total of 162 adolescents (94 females) participated in both baseline (mean age 14.5 +/- 1 years) and three-year follow-up studies. Psychological health was evaluated by self-report using the Beck Youth Inventories of Emotional and Social Impairment and the psychosomatic problem scale. Peripheral endothelial function was assessed using a peripheral artery tonometry device. The HPA-axis activity measured as cortisol awakening response (CAR) was assessed only at follow-up by collecting two saliva samples, immediately after awakening and 15 min later. Physical activity, smoking and parental education were assessed by questionnaires. Results: Adolescents reported increased depression and decreased anger over three years, while only females reported increased psychosomatic complaints. Reduced peripheral endothelial function was associated with high level of anger (beta = -0.332, p = 0.018) and disruptive behaviour (beta = -0.390, p = 0.006) over three years in males, but not in females, after adjusting for covariates. Blunted cortisol awakening response was associated with high level of anxiety (beta = -0.235, p = 0.017), depression (beta = -0.203, p = 0.038), anger (beta = -0.185, p = 0.048), and low level of self-concept (beta = 0.289, p = 0.002) after adjusting for covariates. Conclusions: High level of negative emotions during adolescence may have adverse effects on peripheral endothelial function and the regulation of the HPA- axis activity, while high level of self- concept might be protective. (C) 2017 Elsevier B.V. All rights reserved.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?

Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=255616
Utskriftsdatum: 2019-09-18