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Early hematopoiesis in multiple sclerosis patients

Journal article
Authors Daniel Jons
Maria Kneider
Linda Fogelstrand
Anders Jeppsson
Stefan Jacobsson
Oluf Andersen
Published in Journal of Neuroimmunology
Volume 299
Pages 158-163
ISSN 0165-5728
Publication year 2016
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 158-163
Language en
Links dx.doi.org/10.1016/j.jneuroim.2016....
Keywords Multiple sclerosis, B cell, Precursor, NKT cell, Bone marrow, FACS, EPSTEIN-BARR-VIRUS, CENTRAL-NERVOUS-SYSTEM, KILLER T-CELLS, BONE-MARROW, GLATIRAMER ACETATE, GENE-EXPRESSION, B-CELLS, TRANSPLANTATION, ANTIBODY, PROFILE
Subject categories Hematology, Neurosciences, Immunology in the medical area

Abstract

Contemporary evidence supports that MS immunopathology starts in the peripheral lymphatic system. However, the site and character of crucial initiating events are unknown. We examined subsets of the first stages of blood cells in the bone marrow of 9 MS patients and 11 neurologically healthy controls using FACS analysis. The proportion of natural killer T cells was lower (P = 0.045) in the bone marrow of MS patients, but proportions of hematogenous stem cells, myeloblasts, and B cell precursor subsets in the bone marrow did not differ between MS patients and controls. In this pilot study with a limited number of samples we found no deviation of the early B cell lineage in bone marrow from MS patients. (C) 2016 Elsevier B.V. All rights reserved.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=245517
Utskriftsdatum: 2020-05-30