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A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

Journal article
Authors George M. H. Birchenough
Elisabeth E. L. Nyström
Malin E V Johansson
Gunnar C. Hansson
Published in Science
Volume 352
Issue 6293
Pages 1535-1542
ISSN 0036-8075
Publication year 2016
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 1535-1542
Language en
Links dx.doi.org/10.1126/science.aaf7419
Keywords inflammasome activation, mucosa
Subject categories Clinical Medicine

Abstract

Innate immune signaling pathways contribute to the protection of host tissue when bacterially challenged. Colonic goblet cells are responsible for generating the two mucus layers that physically separate the luminalmicrobiota from the host epithelium. Analysis of colonic tissues from multiple mouse strains allowed us to identify a "sentinel" goblet cell (senGC) localized to the colonic crypt entrance. This cell nonspecifically endocytoses and reacts to the TLR2/1, TLR4, and TLR5 ligands by activating the Nlrp6 inflammasome downstream of TLR-and MyD88-dependent Nox/Duox reactive oxygen species synthesis. This triggers calcium ion-dependent compound exocytosis ofMuc2 mucin fromthe senGC and generates an intercellular gap junction signal; in turn, this signal induces Muc2 secretion from adjacent goblet cells in the upper crypt, which expels bacteria. Thus, senGCs guard and protect the colonic crypt from bacterial intruders that have penetrated the inner mucus layer.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=240027
Utskriftsdatum: 2019-09-16