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Implications of enterotoxigenic Escherichia coli genomics for vaccine development

Journal article
Authors Åsa Sjöling
Astrid von Mentzer
Ann-Mari Svennerholm
Published in Expert Review of Vaccines
Volume 14
Issue 4
Pages 551-560
ISSN 1476-0584
Publication year 2015
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 551-560
Language en
Links dx.doi.org/10.1586/14760584.2015.99...
Keywords colonization factor, enterotoxigenic Escherichia coli, ETEC, ETEC vaccine, genomics, next-generation, CELL CHOLERA VACCINE, HEAT-STABLE TOXIN, FACTOR ANTIGEN-I, COLONIZATION, FACTORS, MOLECULAR CHARACTERIZATION, MONOCLONAL-ANTIBODIES, DIARRHEAL, INFECTIONS, BANGLADESHI CHILDREN, DEVELOPING-COUNTRIES, REVERSE, VACCINOLOGY, Immunology
Subject categories Clinical Medicine

Abstract

Enterotoxigenic Escherichia coli (ETEC) is a major cause of morbidity and mortality caused by diarrhea in children less than 5 years of age in low- and middle-income countries. Despite a wealth of research elucidating the mechanisms of disease, the immunological responses and vaccine development, ETEC is still relatively uncharacterized when it comes to regulation of virulence and detailed immune mechanisms. The recent emergence of next-generation sequencing now offers the possibility to screen genomes of ETEC strains isolated globally to identify novel vaccine targets in addition to those already established. In this review, we discuss how recent findings on ETEC genomics using novel sequencing techniques will aid in finding novel protective antigens that can be used in vaccine approaches.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=215147
Utskriftsdatum: 2019-10-17