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Age and diagnostic performance of Alzheimer disease CSF biomarkers.

Journal article
Authors Niklas Mattsson
E Rosén
O Hansson
N Andreasen
L Parnetti
Michael Jonsson
S-K Herukka
W M van der Flier
M A Blankenstein
M Ewers
K Rich
E Kaiser
M M Verbeek
M Olde Rikkert
M Tsolaki
E Mulugeta
D Aarsland
P J Visser
J Schröder
J Marcusson
M de Leon
H Hampel
P Scheltens
Anders Wallin
M Eriksdotter-Jönhagen
L Minthon
B Winblad
Kaj Blennow
Henrik Zetterberg
Published in Neurology
Volume 78
Issue 7
Pages 468-76
ISSN 1526-632X
Publication year 2012
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 468-76
Language en
Links dx.doi.org/10.1212/WNL.0b013e318247...
Keywords Adult, Aged, Aged, 80 and over, Aging, physiology, Alzheimer Disease, cerebrospinal fluid, diagnosis, Biological Markers, cerebrospinal fluid, Cohort Studies, Cross-Sectional Studies, Endpoint Determination, Female, Humans, Likelihood Functions, Longitudinal Studies, Male, Middle Aged, Mild Cognitive Impairment, cerebrospinal fluid, diagnosis, Models, Neurological, Predictive Value of Tests, ROC Curve, Reproducibility of Results, tau Proteins, cerebrospinal fluid
Subject categories Neurology

Abstract

Core CSF changes in Alzheimer disease (AD) are decreased amyloid β(1-42), increased total tau, and increased phospho-tau, probably indicating amyloid plaque accumulation, axonal degeneration, and tangle pathology, respectively. These biomarkers identify AD already at the predementia stage, but their diagnostic performance might be affected by age-dependent increase of AD-type brain pathology in cognitively unaffected elderly.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=180685
Utskriftsdatum: 2020-04-02