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Interactions between spinal interneurons and ventral spinocerebellar tract neurons.

Journal article
Authors Elzbieta Jankowska
Ingela Hammar
Published in The Journal of physiology
Volume 591
Issue Pt 22
Pages 5445-5451
ISSN 1469-7793
Publication year 2013
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 5445-5451
Language en
Links dx.doi.org/10.1113/jphysiol.2012.24...
https://gup.ub.gu.se/file/140930
Keywords Interneurone, Motor systems, Spinal cord
Subject categories Basic Medicine, Neurophysiology

Abstract

Recent evidence indicates that ventral spinocerebellar tract (VSCT) neurons not merely receive information provided by spinal interneurons but may also modulate the activity of these interneurons. Hence, interactions between them may be mutual. However, while it is well established that spinal interneurons may provide both excitatory and inhibitory input to ascending tract neurons, the functional consequences of the almost exclusively inhibitory input from premotor interneurons to subpopulations of VSCT neurons were only recently addressed. These are discussed in the first part of this review. The second part of the review summarizes evidence that some VSCT neurons may operate both as projection neurons and as spinal interneurons and play a role in spinal circuitry. It outlines the evidence that initial axon collaterals of VSCT neurons target premotor inhibitory interneurons in disynaptic reflex pathways from tendon organs and muscle spindles (group Ia, Ib and/or II muscle afferents) to motoneurons. By activating these interneurons VSCT neurons may evoke disynaptic IPSPs in motoneurons and thus facilitate inhibitory actions of contralateral muscle afferents on motoneurons. In this way they may contribute to the coordination between neuronal networks on both sides of the spinal cord in advance of modulatory actions evoked via the cerebellar control systems.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=180259
Utskriftsdatum: 2020-08-11