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The occupational contribution to severe exacerbation of asthma.

Journal article
Authors P K Henneberger
M C Mirabelli
M Kogevinas
J M Antó
E Plana
Anna Dahlman-Höglund
D L Jarvis
H Kromhout
Linnea Lillienberg
D Norbäck
M Olivieri
K Radon
Kjell Torén
I Urrutia
S Villani
J P Zock
Published in The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
Volume 36
Issue 4
Pages 743-50
ISSN 1399-3003
Publication year 2010
Published at Institute of Medicine, School of Public Health and Community Medicine
Pages 743-50
Language en
Keywords Adult, Asthma, diagnosis, etiology, Disease Progression, Female, Humans, Male, Middle Aged, Models, Statistical, Occupational Diseases, therapy, Occupational Exposure, adverse effects, Occupational Health, Questionnaires, Risk, Risk Factors
Subject categories Health Sciences


The goal of this study was to identify occupational risk factors for severe exacerbation of asthma and estimate the extent to which occupation contributes to these events. The 966 participants were working adults with current asthma who participated in the follow-up phase of the European Community Respiratory Health Survey. Severe exacerbation of asthma was defined as self-reported unplanned care for asthma in the past 12 months. Occupations held in the same period were combined with a general population job-exposure matrix to assess occupational exposures. 74 participants reported having had at least one severe exacerbation event, for a 1-yr cumulative incidence of 7.7%. From regression models that controlled for confounders, the relative risk (RR) was statistically significant for low (RR 1.7, 95% CI 1.1-2.6) and high (RR 3.6, 95% CI 2.2-5.8) biological dust exposure, high mineral dust exposure (RR 1.8, 95% CI 1.02-3.2), and high gas and fumes exposure (RR 2.5, 95% CI 1.2-5.5). The summary category of high dust, gas, or fumes exposure had RR 3.1 (95% CI 1.9-5.1). Based on this RR, the population attributable risk was 14.7% among workers with current asthma. These results suggest occupation contributes to approximately one in seven cases of severe exacerbation of asthma in a working population, and various agents play a role.

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Utskriftsdatum: 2019-10-17