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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.

Review article
Authors Gunnar C. Hansson
Malin E V Johansson
Published in Gut microbes
Volume 1
Issue 1
Pages 51-54
ISSN 1949-0984
Publication year 2010
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 51-54
Language en
Subject categories Chemistry, Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)


We have recently shown that the colon is protected by an inner mucus layer that efficiently separates the bacteria in the outer mucus from the epithelial cells. The inner mucus is impervious for bacteria and built by a network formed by the MUC2 mucin. Lack or defects in this inner mucus layer allow bacteria to reach the epithelia, something that triggers colon inflammation.

Page Manager: Webmaster|Last update: 9/11/2012

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