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Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity

Journal article
Authors C. Wu
D. K. Vanderveen
Ann Hellström
Chatarina Löfqvist
L. E. Smith
Published in Archives of Ophthalmology
Volume 128
Issue 4
Pages 443-447
ISSN 0003-9950
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 443-447
Language en
Links archopht.ama-assn.org/cgi/content/a...
Subject categories Medical and Health Sciences

Abstract

OBJECTIVE: To validate longitudinal postnatal weight gain as a method for predicting severe retinopathy of prematurity (ROP) in a US cohort. METHODS: Both ROP evaluations and weekly weight measurements from birth to postmenstrual week 36 for 318 infants were entered into a computer-based surveillance system, WINROP. This system signaled an alarm when the rate of weight gain decreased compared with control subjects. Infants were classified into 3 groups: (1) no alarm, (2) low-risk alarm, or (3) high-risk alarm. Maximum ROP for each infant was categorized as (1) no ROP (immature or mature vascularization), (2) mild ROP (stage 1 or 2 ROP in zone II or III, without plus disease), or (3) severe ROP (any prethreshold, any stage 3, or threshold ROP). A high-risk alarm identified infants at risk for developing severe ROP. RESULTS: A high-risk alarm occurred in 81 infants (25.5%) and detected all infants who developed severe ROP a median of 9 weeks before diagnosis. The remaining infants received no alarm or a low-risk alarm. None of these infants developed more than mild ROP. CONCLUSIONS: Longitudinal postnatal weight gain may help predict ROP. In a US cohort, the WINROP system had a sensitivity of 100% and identified infants early who developed severe ROP. With further validation, WINROP has the potential to safely reduce the number of ROP examinations.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?publicationId=121695
Utskriftsdatum: 2019-11-22