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Accumulation of CCR4 CTLA-4 FOXP3CD25 Regulatory T Cells in Colon Adenocarcinomas Correlate to Reduced Activation of Conventional T Cells.

Journal article
Authors Helena Svensson
Veronica Olofsson
Samuel B Lundin
Chakradhar Yakkala
Stellan Björck
Lars Börjesson
Bengt Gustavsson
Marianne Quiding-Järbrink
Published in PloS one
Volume 7
Issue 2
Pages article number e30695
ISSN 1932-6203
Publication year 2012
Published at Institute of Clinical Sciences, Department of Surgery
Institute of Biomedicine, Department of Microbiology and Immunology
Pages article number e30695
Language en
Links dx.doi.org/10.1371/journal.pone.003...
Subject categories Surgery

Abstract

Colorectal cancer usually gives rise to a specific anti-tumor immune response, but for unknown reasons the resulting immunity is not able to clear the tumor. Recruitment of activated effector lymphocytes to the tumor is important for efficient anti-tumor responses, while the presence of regulatory T cells (Treg) down-modulate tumor-specific immunity. We therefore aimed to determine homing mechanisms and activation stage of Treg and effector T cell infiltrating colon tumors compared to cells from the unaffected mucosa in patients suffering from colon adenocarcinoma.

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Utskriftsdatum: 2020-07-13