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Mapping functions in health-related quality of life: mapping from the Achilles Tendon Rupture Score to the EQ-5D.

Journal article
Authors Ay-Yen Hua
Olof Westin
Eric Hamrin Senorski
Eleonor Svantesson
Alberto Grassi
Stefano Zaffagnini
Kristian Samuelsson
Mikael Svensson
Published in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Volume 26
Issue 10
Pages 3083-3088
ISSN 1433-7347
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Health and Rehabilitation
Institute of Clinical Sciences, Department of Orthopaedics
Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
Pages 3083-3088
Language en
Subject categories Health Care Service and Management, Health Policy and Services and Health Economy


Health state utility values are derived from preference-based measurements and are useful in calculating quality-adjusted life years (QALYs), which is a metric commonly used in cost-effectiveness studies. The purpose of this study was to convert the Achilles Tendon Rupture Score (ATRS) to the preference-based European Quality of Life-5 Dimension Questionnaire (EQ-5D) by estimating the relationship between the two scores using mapping.Data were collected from a randomised controlled trial, where 100 patients were treated either surgically or non-surgically for Achilles tendon rupture. Forty-three and forty-four patients in surgical group and non-surgical group completed the ATRS and the EQ-5D alongside each other during follow-up at three time points. Different models of the relationship between the ATRS and the EQ-5D were developed and analysed based on direct mapping and cross-validation. The model with the lowest mean absolute error was observed as the one with the best fit.Among the competing models, mapping based on using a combination of the ATRS items four, five, and six associated with limitation due to pain, during activities of daily living and when walking on uneven ground, produced the best predictor of the EQ-5D score.The present study provides a mapping algorithm to enable the derivation of utility values directly from the ATRS. This approach makes it feasible for researchers, as well as medical practitioners, to obtain preference-based values in clinical studies or settings where only the ATRS is being administered. The algorithm allows for the calculation of QALYs for use in cost-effectiveness analyses, making it valuable in the study of acute Achilles tendon ruptures.II.

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