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Cartilage and Bone Regeneration

Chapter in book
Authors Anders Lindahl
Mats Brittberg
D. Gibbs
J. I. Dawson
J. Kanczler
C. Black
R. Tare
R. O. C. Oreffo
Published in Tissue Engineering: Second Edition
Pages 529-582
Publisher Elsevier, Inc.
Place of publication Amsterdam
Publication year 2014
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Institute of Clinical Sciences, Department of Orthopaedics
Pages 529-582
Language en
Keywords Biomaterials, Cartilage, Cartilage regeneration, Chondrocyte transplantation, Hyaluronan, Tissue engineering
Subject categories Bioengineering Equipment, Medical Biotechnology, Medical Materials


This chapter deals with the tissue engineering aspects of one of the mesenchymal tissues-cartilage. It includes a brief description of the different cartilage types and their embryonal origin. Tissue structures including chondrocyte and extracellular matrix components are described in detail. The disease aspect of hyaline cartilage with emphasis on cartilage injuries and the tissue engineering approach to cartilage regeneration with the autologous chondrocyte implantation technique is described in depth. The future aspects of cartilage regeneration techniques with potential cell types other than autologous chondrocytes as well as new promising scaffold techniques are described. © 2015 Elsevier Inc. All rights reserved.

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