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Urinary stone disease and obesity: Different pathologies sharing common biochemical mechanisms.

Review article
Authors Özgu Aydogdu
Published in World journal of nephrology
Volume 1
Issue 1
Pages 12-5
ISSN 2220-6124
Publication year 2012
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 12-5
Language en
Links dx.doi.org/10.5527/wjn.v1.i1.12
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Endocrinology, Urology and Nephrology, Kidney diseases, Urology and andrology, Clinical Medicine

Abstract

The prevalence of urolithiasis is increasing in parallel with the escalating rate of obesity worldwide. It has previously been speculated that obesity is a potential risk factor for urinary stone disease. The possibility that common biochemical mechanisms underlie both obesity and urolithiasis is remarkable. Better understanding of possible common mechanisms of these diseases could potentially lead to a better management of urinary stone prevention. The prevention of urinary stone formation gives clinicians an acceptable reason to encourage lifestyle modification and weight loss through a regular diet. In this review, the association of obesity with urinary stone disease, possible common biochemical mechanisms, effects of dietary habits and weight loss on stone formation, as well as difficulties in surgical management of obese individuals with urolithiasis are discussed.

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