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Role of mixed lineage kinase inhibition in neonatal hypoxia-ischemia.

Journal article
Authors Ylva Carlsson
Anna-Lena Leverin
Maj Hedtjärn
Xiaoyang Wang
Carina Mallard
Henrik Hagberg
Published in Developmental neuroscience
Volume 31
Issue 5
Pages 420-6
ISSN 1421-9859
Publication year 2009
Published at Institute of Neuroscience and Physiology, Department of Physiology
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 420-6
Language en
Links dx.doi.org/10.1159/000232560
Subject categories Medical and Health Sciences

Abstract

Hypoxic-ischemic brain injury is often delayed and involves both apoptotic and immunoregulatory mechanisms. In this study, we used a neonatal model of hypoxia-ischemia to examine the effect of the mixed lineage kinase (MLK) inhibitor CEP-1347 on brain damage, apoptosis and inflammation. The tissue volume loss was reduced by 28% (p = 0.019) in CEP-1347-treated versus vehicle-treated rats and CEP-1347 significantly attenuated microgliosis at 7 days (p = 0.038). CEP-1347 decreased TUNEL-positive staining as well as cleaved caspase 3 immunoreactivity. CEP-1347 did not affect the expression of pro-inflammatory cytokines IL-1 beta, IL-6 and MCP-1, nor did it affect the expression of OX-42 (CR3) and OX-18 (MHC I) 24 h after the insult. In conclusion, the MLK inhibitor CEP-1347 has protective effects in a neonatal rat model of hypoxia-ischemia, which is mainly related to reduced apoptosis.

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