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Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals.

Journal article
Authors Andréa L Benedet
Nicholas Ashton
Tharick A Pascoal
Antoine Leuzy
Sulantha Mathotaarachchi
Min S Kang
Joseph Therriault
Melissa Savard
Mira Chamoun
Michael Schöll
Eduardo R Zimmer
Serge Gauthier
Aurélie Labbe
Henrik Zetterberg
Kaj Blennow
Pedro R Neto
Published in Alzheimer's & dementia
Volume 11
Pages 679-689
ISSN 2352-8729
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Wallenberg Centre for Molecular and Translational Medicine
Pages 679-689
Language en
Subject categories Neurosciences


Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. However, there are limited reports of how longitudinal NfL relates to imaging biomarkers. We herein investigated the relationship between blood NfL and brain metabolism in AD.Voxelwise regression models tested the cross-sectional association between [18F]fluorodeoxyglucose ([18F]FDG) and both plasma and cerebrospinal fluid NfL in cognitively impaired and unimpaired subjects. Linear mixed models were also used to test the longitudinal association between NfL and [18F]FDG in amyloid positive (Aβ+) and negative (Aβ-) subjects.Higher concentrations of plasma and cerebrospinal fluid NfL were associated with reduced [18F]FDG uptake in correspondent brain regions. In Aβ+ participants, NfL associates with hypometabolism in AD-vulnerable regions. Longitudinal changes in the association [18F]FDG-NfL were confined to cognitively impaired Aβ+ individuals.These findings indicate that plasma NfL is a proxy for neurodegeneration in AD-related regions in Aβ+ subjects.

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