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Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients.

Journal article
Authors Pia Davidsson
Ann Brinkmalm-Westman
Carol L Nilsson
Maria Lindbjer
Linda Paulson
Niels Andreasen
Magnus Sjögren
Kaj Blennow
Published in Neuroreport
Volume 13
Issue 5
Pages 611-5
ISSN 0959-4965
Publication year 2002
Published at Institute of Clinical Neurosciences
Pages 611-5
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Aged, Aged, 80 and over, Alzheimer Disease, cerebrospinal fluid, Confidence Intervals, Female, Humans, Longitudinal Studies, Male, Patients, statistics & numerical data, Protein Isoforms, cerebrospinal fluid, Proteins, metabolism, Proteome, metabolism, Statistics, Nonparametric
Subject categories Neurobiology

Abstract

By comparing the CSF proteome between Alzheimer disease (AD) patients and controls it may be possible to identify proteins that play a role in the disease process and thus to study the pathogenesis of AD. We used mini-gel technology in a two-dimensional electrophoresis procedure, sensitive SYPRO Ruby staining and mass spectrometry for clinical screening of disease-influenced CSF proteins in 15 AD patients and 12 controls. The levels of six proteins and their isoforms, including proapolipoprotein, apolipoprotein E, beta-2 microglobulin, retinol-binding protein, transthyretin, and ubiquitin, were significantly altered in CSF of AD patients. The most prominently altered proteins were the apolipoproteins, especially proapolipoprotein.

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