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Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease

Journal article
Authors Henrik Ryberg
Ann-Sofi Söderling
Pia Davidsson
Kaj Blennow
Kenneth Caidahl
Lennart I. Persson
Published in Neurochem Int
Volume 45
Issue 1
Pages 57-62
ISSN 0197-0186 (Print)
Publication year 2004
Published at Cardiovascular Institute
Institute of Clinical Neurosciences
Pages 57-62
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Adult, Aged, Aged, 80 and over, Alzheimer Disease/*cerebrospinal fluid, Amyotrophic Lateral Sclerosis/*cerebrospinal fluid, Biological Markers/cerebrospinal fluid, Female, Humans, Male, Middle Aged, Tyrosine/*analogs & derivatives/*cerebrospinal fluid
Subject categories Medical and Health Sciences

Abstract

The mechanisms behind the degeneration of neurons in diseases such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) are not fully understood. However, oxidation of certain amino acid residues in proteins may contribute to cell injury and some of these oxidized amino acids may also be suitable as biomarkers for oxidative injury. Therefore, it is suggested that the reaction between peroxynitrite (ONOO(-)) and tyrosine in vivo can be monitored by monitoring the formation of 3-nitrotyrosine (3-NT). In this work, a newly developed gas chromatographic-mass spectrometric method was applied to human cerebrospinal fluid (CSF). The free 3-NT levels were determined in the CSF from 19 controls, 17 patients with AD and 14 patients with ALS. The levels of free 3-NT in the CSF were considerably lower than those previously reported. The majority of the patients with AD or ALS had free 3-NT levels in the same range as seen in the control individuals and only a few patients showed increased levels of free 3-NT.

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