To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Antisecretory factor modu… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Antisecretory factor modulates GABAergic transmission in the rat hippocampus.

Journal article
Authors Malin Kim
Pontus Wasling
Min-Yi Xiao
Eva Jennische
Stefan Lange
Eric Hanse
Published in Regulatory peptides
Volume 129
Issue 1-3
Pages 109-18
ISSN 0167-0115
Publication year 2005
Published at Institute of Anatomy and Cell Biology
Institute of Laboratory Medicine, Dept of Clinical Bacteriology
Institute of Physiology and Pharmacology, Dept of Physiology
Pages 109-18
Language en
Keywords Animals, Hippocampus, cytology, physiology, Male, Membrane Potentials, drug effects, physiology, Neuropeptides, pharmacology, Organ Culture Techniques, Rats, Rats, Sprague-Dawley, Synaptic Transmission, drug effects, physiology, gamma-Aminobutyric Acid, metabolism
Subject categories Physiology


Antisecretory Factor (AF) is a protein that has been implicated in the suppression of intestinal hypersecretion and inflammation. Intestinal secretion and inflammation are partly under local and central neural control raising the possibility that AF might exert its action by modulating neural signaling. In the present study we have investigated whether AF can modulate central synaptic transmission. Evoked glutamatergic and GABAergic synaptic transmissions were investigated using extracellular recordings in the CA1 region of hippocampal slices from adult rats. AF (0.5 microg/ml) suppressed GABA(A)-mediated synaptic transmission by about 40% while having no effect on glutamatergic transmission. Per oral administration of cholera toxin as well as feeding of rats with a diet containing hydrothermally processed cereals, known to upregulate endogenous AF plasma activity, mimicked the effect of exogenously administered AF on hippocampal GABAergic transmission. Our results identify AF as a neuromodulator and further raise the possibility that the hippocampus and AF are involved in a gut-brain loop controlling intestinal secretion and inflammation.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?