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How the COVID-19 Overcomes the Battle? An Approach to Virus Structure

Review article
Authors Doryaneh Ahmadpour
P. Ahmadpoor
Published in Iranian Journal of Kidney Diseases
Volume 14
Issue 3
Pages 167-172
ISSN 1735-8582
Publication year 2020
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Centre for Ageing and Health (Agecap)
Pages 167-172
Language en
Keywords coronavirus, SARS-CoV-2, spike protein, ACE2, Nsps, ORFs, immune, response, drugs, spike protein, sars, pathogenesis, coronavirus, cov, Urology & Nephrology
Subject categories Virology, Urology and Nephrology


Coronaviruses primarily cause zoonotic infections, however in the past few decades several interspecies transmissions have occurred, the last one by SARS-CoV-2, causing COVID-19 pandemic, posing serious threat to global health. The SARS-CoV-2 spike (S) protein plays an important role in viral attachment, fusion and entry. However, other structural and non-structural SARS-CoV-2 proteins are potential influencers in virus pathogenicity. Among these proteins; Orf3, Orf8, and Orf10 show the least homology to SARS-CoV proteins and therefore should be further studied for their abilities to modulate antiviral and inflammatory responses. Here, we discuss how SARS-COV-2 interacts with our immune system.

Page Manager: Webmaster|Last update: 9/11/2012

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