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Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss

Journal article
Authors Lina Lawenius
Julia M. Scheffler
Karin L. Gustafsson
Petra Henning
Karin H. Nilsson
Hannah Colldén
Ulrika Islander
H. Plovier
P. D. Cani
W. M. de Vos
Claes Ohlsson
Klara Sjögren
Published in American Journal of Physiology-Endocrinology and Metabolism
Volume 318
Issue 4
Pages E480-E491
ISSN 0193-1849
Publication year 2020
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Centre for Bone and Arthritis Research
Institute of Medicine
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages E480-E491
Language en
Links dx.doi.org/10.1152/ajpendo.00425.20...
Keywords Akkermansia, bone mass, gut microbiota, osteoporosis, probiotic, gut microbiota, osteoprotegerin, inflammation, absorption, cells, mice, Endocrinology & Metabolism, Physiology
Subject categories Clinical Medicine

Abstract

Probiotic bacteria can protect from ovariectomy (ovx)-induced bone loss in mice. Akkermansia muciniphila is considered to have probiotic potential due to its beneficial effect on obesity and insulin resistance. The purpose of the present study was to determine if treatment with pasteurized Akkermansia muciniphila (pAkk) could prevent ovx-induced bone loss. Mice were treated with vehicle or pAkk for 4 wk, starting 3 days before ovx or sham surgery. Treatment with pAkk reduced fat mass accumulation confirming earlier findings. However, treatment with pAkk decreased trabecular and cortical bone mass in femur and vertebra of gonadal intact mice and did not protect from ovx-induced bone loss. Treatment with pAkk increased serum parathyroid hormone (PTH) levels and increased expression of the calcium transporter Trpv5 in kidney suggesting increased reabsorption of calcium in the kidneys. Serum amyloid A 3 (SAA3) can suppress bone formation and mediate the effects of PTH on bone resorption and bone loss in mice and treatment with pAkk increased serum levels of SAA3 and gene expression of Saa3 in colon. Moreover, regulatory T cells can be protective of bone and pAkk-treated mice had decreased number of regulatory T cells in mesenteric lymph nodes and bone marrow. In conclusion, treatment with pAkk protected from ovx-induced fat mass gain but not from bone loss and reduced bone mass in gonadal intact mice. Our findings with pAkk differ from some probiotics that have been shown to protect bone mass, demonstrating that not all prebiotic and probiotic factors have the same effect on bone.

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