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Understanding the role of diabetes in the osteoarthritis disease and treatment process: a study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort

Journal article
Authors A. Dell'Isola
Johanna Vinblad
S. Lohmander
Ann-Marie Svensson
A. Turkiewicz
Stefan Franzén
E. Naucler
A. W-Dahl
A. Abbott
L. Dahlberg
Ola Rolfson
M. Englund
Published in Bmj Open
Volume 9
Issue 12
ISSN 2044-6055
Publication year 2019
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Institute of Clinical Sciences, Department of Orthopaedics
Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
Language en
Keywords population, mellitus, classification, management, criteria, impact, hip, General & Internal Medicine
Subject categories Internal medicine


Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type II diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycaemia toxicity and physical inactivity have been suggested as potential links between diabetes and OA, and have been shown to negatively impact patients' health and quality of life. However, little is known on the role of diabetes in determining the outcome of non-surgical and surgical management of OA, and at the same time, how different OA interventions may affect diabetes control. Thus, the overall aim of this project is to explore (1) the impact of diabetes on the outcome of non-surgical and surgical OA treatments and (2) the impact of non-surgical and surgical OA treatments on diabetes control. Methods and analysis The study cohort is based on prospectively ascertained register data on a national level in Sweden. Data from OA patients who received a first-line non-surgical intervention and are registered in the National Quality Register for Better Management of Patients with Osteoarthritis will be merged with data from the Swedish Knee and Hip Arthroplasty Registers and the National Diabetes Register. Additional variables regarding patients' use of prescribed drugs, comorbidities, socioeconomic status and cause of death will be obtained through other national health and population data registers. The linkage will be performed on an individual level using unique personal identity numbers. Ethics and dissemination This study received ethical approval (2019-02570) from the Swedish Ethical Review Authority. Results from this cohort will be submitted to peer-reviewed scientific journals and reported at the leading national and international meetings in the field.

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