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Systems biology perspective for studying the gut microbiota in human physiology and liver diseases

Journal article
Authors O. Altay
J. Nielsen
M. Uhlen
Jan Borén
A. Mardinoglu
Published in Ebiomedicine
Volume 49
Pages 364-373
ISSN 2352-3964
Publication year 2019
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 364-373
Language en
Subject categories Biological Sciences


The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of human microbiome research has greatly evolved and the relative contribution of the gut microbiome to health and disease have been systematically explored. This review provides an overview of the network-based and translational systems biology-based studies focusing on the function and composition of gut microbiota. We also discussed the association between the gut microbiome and the overall human physiology, as well as hepatic diseases and other metabolic disorders. (c) 2019 The Author(s). Published by Elsevier B.V.

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