To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

An ultrafast system for s… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

An ultrafast system for signaling mechanical pain in human skin

Journal article
Authors S. S. Nagi
A. G. Marshall
A. Makdani
E. Jarocka
Jaquette Liljencrantz
M. Ridderstrom
S. Shaikh
F. O'Neill
D. Saade
S. Donkervoort
A. R. Foley
J. Minde
M. Trulsson
J. Cole
C. G. Bonnemann
A. T. Chesler
M. C. Bushnell
F. McGlone
H. Olausson
Published in Science Advances
Volume 5
Issue 7
ISSN 2375-2548
Publication year 2019
Published at Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Language en
Keywords a-delta-fibers, unmyelinated tactile afferents, sensory nerve-endings, hairy skin, intraneural microstimulation, conduction velocities, nociceptive messages, cutaneous afferents, response properties, stimulation, Science & Technology - Other Topics
Subject categories Neurosciences


The canonical view is that touch is signaled by fast-conducting, thickly myelinated afferents, whereas pain is signaled by slow-conducting, thinly myelinated ("fast" pain) or unmyelinated ("slow" pain) afferents. While other mammals have thickly myelinated afferents signaling pain (ultrafast nociceptors), these have not been demonstrated in humans. Here, we performed single-unit axonal recordings (microneurography) from cutaneous mechanoreceptive afferents in healthy participants. We identified A-fiber high-threshold mechanoreceptors (A-HTMR5) that were insensitive to gentle touch, encoded noxious skin indentations, and displayed conduction velocities similar to A-fiber low-threshold mechanoreceptors. Intraneural electrical stimulation of single ultrafast A-HTMRs evoked painful percepts. Testing in patients with selective deafferentation revealed impaired pain judgments to graded mechanical stimuli only when thickly myelinated fibers were absent. This function was preserved in patients with a loss-of-function mutation in mechanotransduction channel PIEZO2.These findings demonstrate that human mechanical pain does not require PIEZO2 and can be signaled by fast-conducting, thickly myelinated afferents.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?