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Investigation of sparse clinical sampling in light of baseline oscillations and between‐individual variability using pharmacokinetic/pharmacodynamic modelling

Authors Felix Held
C. Ekstrand
J. Gabrielsson
Mats Jirstrand
Published in Journal of Veterinary Pharmacology and Therapeutics. Special Issue 14th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Wroclaw, Poland, June 24‐27, 2018, pp146-148
ISSN 1365-2885
Publication year 2018
Published at Department of Mathematical Sciences
Language en
Subject categories Veterinary Science


Cortisol exhibits a circadian rhythm in horses. It is a well‐known biomarker that is suppressed by dexamethasone. A sampling protocol of cortisol with one pre‐ and one post drug administration sample is used in dexamethasone suppression tests. However, diurnal fluctuation and inter‐individual variation may hamper the utility of test results. The aim of this study was to quantify the determinants of baseline fluctuation and between‐individual and between‐occasion variability for guidance of an improved test protocol.

Page Manager: Webmaster|Last update: 9/11/2012

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