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Drug Therapy in Obstructive Sleep Apnea

Review article
Authors Jan A Hedner
Ding Zou
Published in Sleep Medicine Clinics
Volume 13
Issue 2
Pages 203-17
ISSN 1556-407X
Publication year 2018
Published at Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 203-17
Language en
Links doi.org/10.1016/j.jsmc.2018.03.004
Keywords Sleep, Obstructive sleep apnea, Drug, Medication, Therapy, positive airway pressure, hormone replacement therapy, randomized, controlled-trial, residual excessive sleepiness, genioglossus, muscle-activity, congestive-heart-failure, placebo-controlled trial, double-blind, blood-pressure, postmenopausal women
Subject categories Pharmacology and Toxicology

Abstract

There are several reasons to develop a pharmacologic remedy in obstructive sleep apnea (OSA); but so far, there is no generally effective drug available. Previous attempts to find a drug in OSA therapy were serendipity driven in small pilot trials. There is a growing literature on phenotyping pathophysiologic mechanisms of OSA that may be exploited in strategic drug development programs. This article addresses potential pitfalls encountered in previous studies and highlights several drug candidates under development in the field.

Page Manager: Webmaster|Last update: 9/11/2012
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