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Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies

Journal article
Authors Bani Ahluwalia
Luiza Moraes
Maria K Magnusson
Lena Öhman
Published in Scandinavian Journal of Gastroenterology
Volume 53
Issue 4
Pages 379-389
ISSN 0036-5521
Publication year 2018
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 379-389
Language en
Links https://doi.org/10.1080/00365521.20...
Keywords IBD, immunopathogenesis, Crohn's disease, ulcerative colitis, chronic inflammation, dysregulated, innate lymphoid-cells, severe crohns-disease, placebo-controlled trial, regulatory t-cell, intestinal epithelial-cells, toll-like receptor-9, anti-tnf therapy, ulcerative-colitis, dendritic cells, maintenance, therapy, Gastroenterology & Hepatology
Subject categories Gastroenterology and Hepatology

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of reach and, therefore, treatment is far from ideal. Nevertheless, components involved in IBD pathogenesis including environmental, genetic, microbial, and immunological factors are continuously being investigated and the improved knowledge contributes to the development of new therapies. In this article we review the aspects of the immunopathogenesis of IBD, with focus on mucosal immunity, and discuss mechanisms of action for current and emerging biological therapies.

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