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The highest mortality rates in childhood dilated cardiomyopathy occur during the first year after diagnosis.

Journal article
Authors Shalan Fadl
Håkan Wåhlander
Katja Fall
Yang Cao
Jan Sunnegårdh
Published in Acta paediatrica
Volume 107
Issue 4
Pages 672-677
ISSN 1651-2227
Publication year 2018
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages 672-677
Language en
Links dx.doi.org/10.1111/apa.14183
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Pediatrics

Abstract

The aim of the study was to assess the incidence, mortality and morbidity of dilated cardiomyopathy (DCM) and non-compaction of the left ventricle (LVNC) in Swedish children.We reviewed hospital records of all children with dilated cardiomyopathy (DCM) or left ventricular non-compaction cardiomyopathy (LVNC) up to the age of 18 in the healthcare region of western Sweden from 1991 to 2015.In total, 69 cases (61% males) were identified. The combined incidence of DCM and LVNC was 0.77 (95% CI 0.59-0.96) per 100,000 person years. Children were divided into six groups and their outcomes were analysed depending on their aetiology. Idiopathic DCM was reported in 43% and familial dilated and left ventricular non-compaction aetiology was present in 32%. DCM due to various diseases occurred in 8%. DCM associated with neuromuscular diseases was present in 16%. The overall risk of death or receiving transplants in children with idiopathic and familial DCM was 30% over the study period and 21% died in the first year after diagnosis.The combined incidence of DCM and LVNC was similar to previous reports. Most children with idiopathic DCM presented during infancy and mortality was highest during the first year after diagnosis. This article is protected by copyright. All rights reserved.

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