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Antimicrobial Peptides : An Emerging Category of Therapeutic Agents

Journal article
Authors Margit Mahlapuu
J. Hakansson
L. Ringstad
Camilla Björn
Published in Frontiers in Cellular and Infection Microbiology
Volume 6
ISSN 2235-2988
Publication year 2016
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Language en
Links dx.doi.org/10.3389/fcimb.2016.00194
Keywords AMP, antimicrobial peptide, anti-infectives, antibiotic resistance, therapeutic agents, host-defense peptides, pseudomonas-aeruginosa, bacterial-infections, clinical-applications, human keratinocytes, cathelicidin ll-37, lipid, nanocapsules, cell-proliferation, monocytic cells, drug-delivery, Immunology, Microbiology
Subject categories Microbiology

Abstract

Antimicrobial peptides (AMPs), also known as host defense peptides, are short and generally positively charged peptides found in a wide variety of life forms from microorganisms to humans. Most AMPs have the ability to kill microbial pathogens directly, whereas others act indirectly by modulating the host defense systems. Against a background of rapidly increasing resistance development to conventional antibiotics all over the world, efforts to bring AMPs into clinical use are accelerating. Several AMPs are currently being evaluated in clinical trials as novel anti-infectives, but also as new pharmacological agents to modulate the immune response, promote wound healing, and prevent post-surgical adhesions. In this review, we provide an overview of the biological role, classification, and mode of action of AMPs, discuss the opportunities and challenges to develop these peptides for clinical applications, and review the innovative formulation strategies for application of AMPs

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