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Clinical Features, Complications and Autoimmunity in Male Lichen Sclerosus.

Journal article
Authors Despoina Kantere
Gunilla Alvergren
Martin Gillstedt
Fani Pujol-Calderón
Petra Tunbäck
Published in Acta dermato-venereologica
Volume 97
Issue 3
Pages 365–369
ISSN 1651-2057
Publication year 2017
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 365–369
Language en
Links dx.doi.org/10.2340/00015555-2537
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Dermatology and Venereal Diseases

Abstract

Lichen sclerosus is a chronic inflammatory disease associated with substantial morbidity. Knowledge of the aetiology and progression of lichen sclerosus is therefore needed. In this cross-sectional study, 100 male patients diagnosed with lichen sclerosus were interviewed and examined. Since there is a possible link between lichen sclerosus and autoimmunity, blood tests were analysed for thyroid disease, antinuclear antibodies and antibodies to extracellular matrix protein 1, but autoimmunity was found to be infrequent. In 72 participants active genital lichen sclerosis was observed and complications were common; 27 patients had preputial constriction and 12 meatal engagement. In total, 13 patients needed a referral to the Department of Urology, including 1 patient with suspected penile cancer. In conclusion, despite available treatment with ultra-potent steroids and circumcision, LS in males is frequently complicated by phimosis and meatal stenosis. However, the disease can also go into remission, as seen in 27% of our patients.

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