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Casein Kinase 2 - A Kinase that Inhibits Brown Fat Formation

Journal article
Authors Sven Enerbäck
Published in Cell Metabolism
Volume 22
Issue 6
Pages 958-959
ISSN 1550-4131
Publication year 2015
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Pages 958-959
Language en
Links dx.doi.org/10.1016/j.cmet.2015.11.0...
Keywords Article; brown adipocyte; brown adipose tissue; cell differentiation; cell line; cell proliferation; enzyme activation; enzyme activity; enzyme inhibition; human; lipid composition; non insulin dependent diabetes mellitus; nonhuman; obesity; priority journal; protein phosphorylation; proteomics; regulatory mechanism; white adipocyte; adipocyte; brown adipose tissue; energy metabolism; metabolism
Subject categories Biomaterials Science, Cell and molecular biology

Abstract

In adipose tissue, there is a delicate balance between storing and expending energy. In this issue, Shinoda et al. (2015) use phosphoproteomics to identify casein kinase 2 (CK2) as a suppressor of brown adipocyte formation, providing insights into how adipose tissue regulates its composition of white versus brown adipocytes. © 2015 Elsevier Inc.

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