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CD244 is expressed on dendritic cells and regulates their functions

Journal article
Authors A. M. Georgoudaki
S. Khodabandeh
S. Puiac
C. M. Persson
M. K. Larsson
M. Lind
O. Hammarfjord
T. H. Nabatti
R. P. A. Wallin
Ulf Yrlid
M. Rhen
V. Kumar
B. J. Chambers
Published in Immunology and Cell Biology
Volume 93
Issue 6
Pages 581-590
ISSN 0818-9641
Publication year 2015
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 581-590
Language en
Links dx.doi.org/10.1038/icb.2014.124
Keywords COLONY-STIMULATING FACTOR, NATURAL-KILLER-CELLS, NK-CELLS, CUTTING EDGE, IMMUNE-RESPONSES, 2B4 CD244, 2B4/CD48 INTERACTIONS, MOLECULAR-BASIS, SLAM FAMILY, T-CELLS, Cell Biology, Immunology
Subject categories Immunology in the medical area

Abstract

Signaling lymphocytic activation molecule (SLAM) receptors have an important role in the development of immune responses because of their roles, for exampe, in NK cell cytotoxicity and cytokine production by NK, T cells and myeloid cells. The SLAM receptor CD244 (2B4, SLAMf4) is expressed on a variety of immune cell types but most of its functions have been examined on NK and T cells. In the present study, we investigated expression and function of CD244 in murine subsets of dendritic cells (DCs). We report that all subsets of murine DCs examined expressed CD244, although the expression levels of CD244 varied between subsets. Splenic and resident mesenteric lymph node (MLN) DCs from CD244(-/-) mice expressed lower levels of CD86 and MHC class II compared with wild-type mice. Upon Toll-like receptor (TLR) stimulation, no differences in surface expression of these molecules were observed between DCs from CD244(-/-) and wild-type mice. However, splenic DCs from CD244(-/-) mice upon stimulation with TLR binding ligands lipopolysaccharide (LPS) and CpG produced significantly higher levels of pro-inflammatory cytokines. In addition, DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs.

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