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Gas, dust, and fumes exposure is associated with mite sensitization and with asthma in mite-sensitized adults.

Journal article
Authors Anders Bjerg
Erik P Rönmark
Stig Hagstad
Jonas Eriksson
M Andersson
Göran Wennergren
Kjell Torén
Linda Ekerljung
Published in Allergy. European Journal of Allergy and Clinical Immunology
Volume 70
Issue 5
Pages 604-607
ISSN 0105-4538
Publication year 2015
Published at Institute of Medicine, School of Public Health and Community Medicine
Krefting Research Centre
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Institute of Clinical Sciences, Department of Pediatrics
Pages 604-607
Language en
Links dx.doi.org/10.1111/all.12584
Subject categories Respiratory Medicine and Allergy, Pediatrics

Abstract

Occupational exposure to gas, dust, and fumes (GDF) increases the risk of asthma and eczema. We investigated the role of sensitization in the association between GDF and allergic conditions. A population-based sample of 788 adults from the West Sweden Asthma Study completed questionnaires and skin prick tests. After adjustment for confounders, GDF exposure was associated with a doubled risk of sensitization to mites, but not with other allergens. Mite sensitization also modified the effect of GDF on asthma. In mite-sensitized subjects, GDF was associated with physician-diagnosed asthma, adjusted OR 2.9 (1.2-7.2), and with wheeze, OR 2.4 (1.1-5.3). In non-mite-sensitized subjects, the corresponding ORs were 1.1 (0.5-2.6) and 0.6 (0.3-1.3). GDF was independently associated with eczema regardless of mite sensitization, but not with rhinitis. These novel findings suggest that components of GDF may act as adjuvants that facilitate sensitization to mites and that mite-sensitized individuals may be especially susceptible to inhalant occupational exposures.

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