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Health risk assessment and DNA damage of volatile organic compounds in car painting houses

Journal article
Authors P. Siripongpokin
V. Cheevaporn
N. Tangkrock-Olan
Herbert F Helander
Published in EnvironmentAsia
Volume 7
Issue 2
Pages 142-151
ISSN 1906-1714
Publication year 2014
Published at Institute of Clinical Sciences, Department of Surgery
Pages 142-151
Language en
Links www.tshe.org/ea/pdf/vol7no2-17.pdf
Keywords Car painting houses, DNA damage, Health risk assessment, Tail moment, TWA, Volatile organic compounds, automobile, benzene, cancer, concentration (composition), DNA, health risk, metabolite, risk assessment, toluene, volatile organic compound, xylene, Northern Region [Thailand], Phitsanulok, Thailand
Subject categories Environmental Sciences, Environmental medicine

Abstract

Car painters who work near volatile organic compounds (VOCs) sources, including paints, solvents and painting processes may be exposed to highly elevated VOCs levels. This study investigates air samples from car painting houses in in Thailand to evaluate the health risks following inhalation exposure. Personal air samplings were obtained at nine garages in Phitsanulok, Thailand from June to September 2012. The concentrations of benzene, toluene, ethylbenzene, xylenes, and styrene in the air workplaces were significantly higher than in a control group of office workers (p<0.05). Toluene, xylene and ethylbenzene were the most abundant species. However, all VOCs in these air samples were lower than TWA limit of Thailand and the OSHA standard. The lifetime cancer and non-cancer risks for the workers exposed to VOCs were also assessed. The average lifetime cancer risk was 41.0 (38.2-47.2) per million, which is in the acceptable risk. The average lifetime non-cancer risk, the HI, was 0.962 (0.643-1.397), which is well below the reference hazard level. Urine samples, collected after 8-h work periods which were analyzed for VOCs metabolites, including t,t muconic acid, hippuric acid, mandelic acid and m-hippuric acid, demonstrate that the average levels of metabolites in car painters and in controls were close. All VOCs metabolites in urine samples were lower than BEI of ACGIH standard. Blood samples, collected after 8-h work periods which were analyzed by single cell gel electrophoresis (comet) assay. The DNA damage, assessed by tail moment, demonstrates that the average of tail moment in car painters were significantly higher than in the controls (p<0.05).

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