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Presence of CD3-Positive T-Cells in Oral Premalignant Leukoplakia Indicates Prevention of Cancer Transformation

Journal article
Authors Jenny Öhman
Rakeeba Mowjood
Lena Larsson
Anikó Kovács
Bengt Magnusson
Göran Kjeller
Mats Jontell
Bengt Hasséus
Published in Anticancer Research
Volume 35
Issue 1
Pages 311-317
ISSN 0250-7005
Publication year 2015
Published at Institute of Odontology
Institute of Odontology, Section 1
Institute of Biomedicine, Department of Pathology
Institute of Odontology, Section 2
Pages 311-317
Language en
Links ar.iiarjournals.org/content/35/1/31...
Keywords Premalignant leukoplakia, oral cancer, immunosurveillance, biomolecular markers, DENDRITIC CELLS, EPITHELIAL DYSPLASIA, PROGNOSTIC VALUE, CARCINOMA, P53, EXPRESSION, HEAD, NECK, IMMUNOSURVEILLANCE, SURVIVAL, Oncology
Subject categories Cancer and Oncology

Abstract

Aim: Leukoplakias (LPLs) are lesions in the oral mucosa that have a potential to transform into oral squamous cell carcinoma (OSCC). As the degree of immunosurveillance may be important for this transformation to occur, the aim of this study was to determine the presence of immune cells in LPLs with dysplasia in relation to later development of OSCC. Materials and Methods: Biopsies from 16 patients with clinical diagnosis of LPL and histopathological diagnosis of hyperkeratosis with dysplasia were immunostained with antibodies to detect CD3(+) T cells, CD1a(+) LCs, Ki-67(+) and p53-expressing cells. Patients were divided into two groups: LPL with dysplasia that transformed into OSCC (LPL-dys) and that which did not (LPL-ca). Results: Quantitative analyses showed significantly lower numbers of CD3+ T-cells in LPL-ca than in LPL-dys. No significant differences were detected when comparing LPL-dys and LPL-ca regarding CD1a(+), p53(+) and Ki-67(+) cells. Conclusion: The number of CD3-expressing T-cells may be important for preventing malignant transformation of LPL.

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