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Real-time monitoring of surface-confined platelet activation on TiO2

Journal article
Authors Angelika Kunze
Camilla Hesse
Sofia Svedhem
Published in Colloids and Surfaces B: Biointerfaces
Volume 116
Pages 446-451
ISSN 0927-7765
Publication year 2014
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Pages 446-451
Language en
Keywords Aggregation, Platelet activation, QCM-D, TiO2
Subject categories Biological physics


For the development of advanced hemocompatible biomaterial functions, there is an unmet demand for in vitro evaluation techniques addressing platelet-surface interactions. We show that the quartz crystal microbalance with dissipation (QCM-D) monitoring technique, here combined with light microscopy, provides a surface sensitive technique that allows for real-time monitoring of the activation and aggregation of the surface-confined platelets on TiO2. The QCM-D signal monitored during adhesion and activation of platelets on TiO2 coated surfaces was found to be different in platelet-poor and platelet-rich environment although light microscopy images taken for each of the two cases looked essentially the same. Interestingly, aggregation of activated platelets was only observed in a protein-rich environment. Our results show that a layer of plasma proteins between the TiO2 surface and the platelets strongly influences the coupling between the platelets and the underlying substrate, explaining both the observed QCM-D signals and the ability of the platelets to aggregate. © 2014 The Authors.

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