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Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.

Journal article
Authors Marta Perez-Alcazar
Jonny Daborg
Anna Stokowska
Pontus Wasling
Andreas Björefeldt
Marie Kalm
Henrik Zetterberg
Karl E Carlström
Klas Blomgren
Christine T Ekdahl
Eric Hanse
Marcela Pekna
Published in Experimental neurology
Volume 253C
Pages 154-164
ISSN 1090-2430
Publication year 2014
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Clinical Sciences, Department of Pediatrics
Pages 154-164
Language en
Links dx.doi.org/10.1016/j.expneurol.2013...
Keywords Complement cascade, Development, Epilepsy, Hippocampus, Synapse elimination
Subject categories Pediatrics

Abstract

Previous work implicated the complement system in adult neurogenesis as well as elimination of synapses in the developing and injured CNS. In the present study, we used mice lacking the third complement component (C3) to elucidate the role the complement system plays in hippocampus-dependent learning and synaptic function. We found that the constitutive absence of C3 is associated with enhanced place and reversal learning in adult mice. Our findings of lower release probability at CA3-CA1 glutamatergic synapses in combination with unaltered overall efficacy of these synapses in C3 deficient mice implicate C3 as a negative regulator of the number of functional glutamatergic synapses in the hippocampus. The C3 deficient mice showed no signs of spontaneous epileptiform activity in the hippocampus. We conclude that C3 plays a role in the regulation of the number and function of glutamatergic synapses in the hippocampus and exerts negative effects on hippocampus-dependent cognitive performance.

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