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Somatostatin receptors on neuroendocrine tumors--a way to intraoperative diagnosis and localization.

Journal article
Authors Håkan Ahlman
Lars-Eric Tisell
Bo Wängberg
Ola Nilsson
M Fjälling
Eva Forssell-Aronsson
Published in The Yale journal of biology and medicine
Volume 67
Issue 3-4
Pages 215-21
ISSN 0044-0086
Publication year 1994
Published at Institute of Selected Clinical Sciences, Department of Radiation Physics
Institute of Surgical Sciences, Department of Surgery
Pages 215-21
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Carcinoid Tumor, diagnosis, surgery, Carcinoma, Neuroendocrine, diagnosis, surgery, Evaluation Studies as Topic, Humans, Intestinal Neoplasms, diagnosis, surgery, Monitoring, Intraoperative, methods, Octreotide, analogs & derivatives, diagnostic use, Pentetic Acid, analogs & derivatives, diagnostic use, Radionuclide Imaging, methods, Receptors, Somatostatin, isolation & purification, Thyroid Neoplasms, diagnosis, surgery
Subject categories Gastroenterology and Hepatology, Cancer and Oncology, Surgery

Abstract

Intraoperative radionuclide detection using 111In-DTPA-D-Phe1-octreotide was evaluated in five patients with midgut carcinoids and in three patients with recurrent medullary thyroid carcinoma. Three different time intervals (24, 48 and 120 hr) from injection of the radiopharmaceutical to surgery were used. At surgery, suspect tumors were measured by probe in situ and ex vivo after excision. All tissue specimens and blood samples withdrawn during surgery were measured for 111In activity, and tissue/blood activity concentration ratios were calculated. In situ measurements were valuable especially in neck surgery, where the probe was helpful not only in localization of tumors but also in the control of tumor clearance. Ex vivo measurements were helpful in diagnosing tumor tissue. All five patients with midgut carcinoids were somatostatin receptor-positive, while only three out of seven patients with medullary thyroid carcinoma were receptor-positive. The tissue/blood activity concentration ratios and probe measurement ratios were in general higher in patients with midgut carcinoid than in patients with medullary thyroid carcinoma. Of particular interest were the high tissue/blood concentration ratios in all receptor-positive patients at all time intervals studied. This fact suggests a potential role for radiolabelled octreotide in radiotherapy of these tumor types.

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