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Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling

Journal article
Authors Margareta Scharin Täng
Björn Redfors
Malin Lindbom
Johan Svensson
Truls Råmunddal
Claes Ohlsson
Yangzhen Shao
Elmir Omerovic
Published in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Volume 22
Issue 6
Pages 206-211
ISSN 1096-6374
Publication year 2012
Published at Wallenberg Laboratory
Centre for Bone and Arthritis Research
Pages 206-211
Language en
Links dx.doi.org/10.1016/j.ghir.2012.09.0...
Subject categories Cardiac and Cardiovascular Systems, Cardiovascular medicine

Abstract

IGF-1 plays an important role in cardiovascular homeostasis, and plasma levels of IGF-1 correlate inversely with systolic function in heart failure. It is not known to what extent circulating IGF-1 secreted by the liver and local autocrine/paracrine IGF-1 expressed in the myocardium contribute to these beneficial effects on cardiac function and morphology. In the present study, we used a mouse model of liver-specific inducible deletion of the IGF-1 gene (LI-IGF-1 -/- mouse) in an attempt to evaluate the importance of circulating IGF-I on cardiac morphology and function under normal and pathological conditions, with an emphasis on its regulatory role in myocardial phosphocreatine metabolism. Echocardiography was performed in LI-IGF-1 -/- and control mice at rest and during dobutamine stress, both at baseline and post myocardial infarction (MI). High-energy phosphate metabolites were compared between LI-IGF-1 -/- and control mice at 4weeks post MI. We found that LI-IGF-1 -/- mice had significantly greater left ventricular dimensions at baseline and showed a greater relative increase in cardiac dimensions, as well as deterioration of cardiac function, post MI. Myocardial creatine content was 17.9% lower in LI-IGF-1 -/- mice, whereas there was no detectable difference in high-energy nucleotides. These findings indicate an important role of circulating IGF-1 in preserving cardiac structure and function both in physiological settings and post MI.

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