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Effects of doxorubicin on myocardial expression of apolipoprotein-B.

Journal article
Authors Björn Redfors
Yangzhen Shao
Truls Råmunddal
Malin Lindbom
Margareta Scharin Täng
Pia Stillemark-Billton
Jan Borén
Elmir Omerovic
Published in Scandinavian Cardiovascular Journal
Volume 46
Issue 2
Pages 93-98
ISSN 1401-7431
Publication year 2012
Published at Wallenberg Laboratory
Pages 93-98
Language en
Links dx.doi.org/10.3109/14017431.2012.65...
Keywords doxorubicin, heart failure, apolipoprotein B100, acute myocardial infarction
Subject categories Cardiovascular medicine

Abstract

Abstract OBJECTIVE: Doxorubicin (DOX) is an effective antitumour agent against a variety of human malignancies but is associated with deleterious side effects, including myocardial damage and heart failure. Myocardial apoB-containing lipoprotein (apoB) is upregulated post myocardial infarction and has been shown to be cardioprotective in this setting by unloading excessive lipid. The aim of this study was to investigate whether apoB expression is increased also in DOX-induced heart failure and whether apoB overexpression protects the heart in DOX-induced myocardial injury. DESIGN: Cardiac function and energy metabolism was studied in mice and rats 24 hours after intraperitoneally administered DOX. RESULTS: We found that the content of apoB was decreased in rat myocardium 24 hours after DOX injection. In contrast, apoB content was increased in the infarcted myocardium of rats 24 hours post ischemia-reperfusion. Moreover, transgenic mice overexpressing apoB had better cardiac function and lower intracellular lipid accumulation compared to wild type mice 24 hours post DOX.

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