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Time-trends in thrombolytics: women are catching up.

Journal article
Authors Per Johanson
Putte Abrahamsson
Annika Rosengren
Mikael Dellborg
Published in Scandinavian cardiovascular journal : SCJ
Volume 33
Issue 1
Pages 39-43
ISSN 1401-7431
Publication year 1999
Published at Cardiovascular Institute
Pages 39-43
Language en
Keywords Age Factors, Aged, Aged, 80 and over, Chi-Square Distribution, Female, Fibrinolytic Agents, therapeutic use, Humans, Logistic Models, Male, Myocardial Infarction, drug therapy, Retrospective Studies, Sex Factors, Statistics, Nonparametric, Sweden, Thrombolytic Therapy, statistics & numerical data, trends, Time Factors
Subject categories Cardiac and Cardiovascular Systems


Reports on gender differences in the management of acute coronary syndromes indicate that women do not receive as much active treatment as men. Other conflicting findings have also been published. To investigate whether previously reported gender differences in the treatment of acute myocardial infarction (AMI) still persist, we included all patients admitted to our coronary care unit (CCU) in 1984-1995, and discharged with a diagnosis of AMI, in a retrospective study. A total of 1991 female admissions was compared with 4067 male admissions. The time-span was divided into two-year periods comprising approximately 1000 patients each. During one period, 1988 to 1989, women received significantly less thrombolytic therapy which, however, could reflect that women admitted with AMI were older than men. Analysis of time-trends showed a significant increase in the use of thrombolytic treatment in women and elderly men. In clinical praxis there has been a gender-gap in acute treatment of AMI, but age-dependent or not, this is now no longer apparent.

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