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Gene copy number aberrations are associated with survival in histologic subgroups of non-small cell lung cancer.

Journal article
Authors Patrick Micke
Karolina Edlund
Lars Holmberg
Hanna Göransson Kultima
Larry Mansouri
Simon Ekman
Michael Bergqvist
Lena Scheibenflug
Kristina Lamberg
Gunnar Myrdal
Anders Berglund
Annsofie Andersson
Mats Lambe
Fredrik Nyberg
Andrew Thomas
Anders Isaksson
Johan Botling
Published in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Volume 6
Issue 11
Pages 1833-40
ISSN 1556-1380
Publication year 2011
Published at Institute of Medicine, Department of Public Health and Community Medicine
Pages 1833-40
Language en
Links dx.doi.org/10.1097/JTO.0b013e318229...
Subject categories Molecular medicine (genetics and pathology), Cancer and Oncology, Respiratory Medicine and Allergy

Abstract

Non-small cell lung cancer (NSCLC) is characterized by a multitude of genetic aberrations with unknown clinical impact. In this study, we aimed to identify gene copy number changes that correlate with clinical outcome in NSCLC. To maximize the chance to identify clinically relevant events, we applied a strategy involving two prognostically extreme patient groups.

Page Manager: Webmaster|Last update: 9/11/2012
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