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Lipid metabolites in the pathogenesis and treatment of neovascular eye disease.

Journal article
Authors Andreas Stahl
Tim U Krohne
Przemyslaw Sapieha
Jing Chen
Ann Hellström
Emily Chew
Frank G Holz
Lois E H Smith
Published in The British journal of ophthalmology
Volume 95
Issue 11
Pages 1496-1501
ISSN 0007-1161
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 1496-1501
Language en
Subject categories Ophthalmology


Lipids and lipid metabolites have long been known to play biological roles that go beyond energy storage and membrane structure. In age-related macular degeneration and diabetes, for example, dysregulation of lipid metabolism is closely associated with disease onset and progression. At the same time, some lipids and their metabolites can exert beneficial effects in the same disorders. This review summarises our current knowledge of the contributions of lipids to both the pathogenesis and treatment of neovascular eye disease. The clinical entities covered are exudative age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity, with a special emphasis on the potential therapeutic effects of ω3- (also known as n-3) polyunsaturated fatty acids.

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